Cold Outreach Strategies That Actually Work in 2025

The Duct Tape Marketing Podcast with Matthew McQuinn

In this episode of the Duct Tape Marketing Podcast, I interviewed Matthew McQuinn, co-founder of Coldlytics, a company that specializes in research-based lead generation for cold outreach. Matthew has helped digital agencies and B2B businesses refine their cold email strategy, improve outbound sales, and increase client acquisition with targeted, high-quality prospecting lists.

During our conversation, Matthew shared actionable insights on how businesses can improve cold outreach by focusing on personalized, value-driven engagement rather than mass-email tactics. He explained why many cold email campaigns fail, how businesses can leverage AI in sales for better email personalization, and why smaller, highly targeted prospect lists lead to higher response rates.

Matthew’s approach to digital prospecting and B2B marketing is a game-changer for businesses looking to improve cold outreach results. By prioritizing high-quality data, personalization, and multi-channel engagement, companies can increase business growth and close more deals efficiently.

Key Takeaways:

• Quality Over Quantity in Lead Generation – Instead of blasting thousands of emails, focus on a targeted lead generation strategy with high-intent prospects who are more likely to engage.
• Personalization is Key – Generic cold emails don’t work. Use email personalization techniques such as referencing website data, industry involvement, or prior marketing activity to connect with potential clients.
• AI and Automation Can Help—but Only If Used Right – Sales automation tools and AI in sales can improve efficiency, but they should enhance personalization, not replace human connection.
• Multi-Touchpoint Outreach Works Best – Combining email marketing, direct marketing, LinkedIn engagement, and even phone calls creates an omnichannel approach that builds trust faster.
• Success in Outbound Marketing Takes Testing – The best outbound marketing strategies involve constant testing and iteration—optimize email prospecting sequences and messaging for better conversion rates.
• Smaller, More Qualified Lists Convert Better – Instead of sending mass emails to a broad audience, create a refined list of ideal prospects based on industry, company size, and digital marketing activity.

Chapters:

• [00:09] Introduction to Matthew McQuinn
• [00:54] Outreach with Intention and Value
• [02:57] Targeting Your Cold Outreach
• [07:18] How is AI Impacting Lead Generation?
• [10:51] What Works to Generate Leads
• [14:14] Brand, Privacy, and Effective Outreach
• [16:44] Qualifying Leads
• [21:10] The Most Effective Form of Outreach

More About Matt McQueen: 

This episode of the Duct Tape Marketing Podcast is brought to you by

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AdCritter, Matthew McQuinn